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Dietary fat composition modifies the effect of boron on bone characteristics and plasma lipids in rats
Author(s) -
Nielsen Forrest H.
Publication year - 2004
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520200305
Subject(s) - canola , weaning , femur , zoology , chemistry , endocrinology , offspring , medicine , boron , phospholipid , biology , food science , biochemistry , surgery , pregnancy , genetics , organic chemistry , membrane
Female and male rats weighing about 170 g and 200 g, respectively, were fed diets (∼70 μ boron/kg) in a factorial arrangement with supplemental boron at 0 (deficient) and 3 (adequate) mg/kg and canola oil or palm oil at 75 g/kg of diet as variables. After 5 weeks, six females in each treatment were bred. Dams and pups continued on their respective dietary treatments through gestation, lactation and post‐weaning. Thirteen weeks after weaning, plasma and bones were collected from 12 male and 12 female offspring in each treatment. Boron supplementation increased femur strength measured by the breaking variable bending moment; tibial calcium and phosphorus concentrations; and plasma alkaline phosphatase. Femur breaking stress was greatest in boron‐supplemented rats fed canola oil, and lowest in boron‐deprived females fed canola oil; this group also exhibited the lowest femur bending moment. Minerals associated with bone organic matrix, zinc and potassium, were increased by boron supplementation in tibia. Plasma phospholipids were decreased by boron deprivation in females, but not males. Plasma cholesterol was decreased in boron‐supplemented males by replacing canola oil with palm oil. The findings suggest that a diet high in omega‐3 α‐linolenic acid promotes femur strength best when the dietary boron is adequate.