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The effects of Coenzyme Q 10 on locomotor and behavioral activity in young and aged C57BL/6 mice
Author(s) -
Sinatra Drew S.,
Sinatra Stephen T.,
Heyser Charles J.
Publication year - 2003
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520180232
Subject(s) - coenzyme q10 , open field , psychomotor learning , c57bl/6 , locomotor activity , psychology , medicine , endocrinology , physiology , neuroscience , cognition
To explore the possibility that Coenzyme Q 10 (CoQ 10 ) supplementation stabilizes psychomotor behavioral function in the aging organism, the behavioral effects of CoQ 10 were evaluated in young adult male C57BL/6 mice (3 months of age) and aged C57BL/6 mice (24 months of age). Mice treated with CoQ 10 exhibited significantly greater locomotor activity as reflected by an increase in square crosses than non‐drug controls. The administration of CoQ 10 increased all aspects of exploratory behavior in the open field. The effect was uniform across all mice and did not interact with age. Younger animals and aged animals treated with CoQ 10 may adapt rapidly to novel areas, or they are less fearful of exploration. The behavioral activation observed in CoQ 10 treated mice may be the result of increased locomotor activity, psychomotor stimulation, or decreased anxiety.