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Coenzyme Q, Vitamin E and Apo‐E alleles in Alzheimer Disease
Author(s) -
Battino M.,
Bompadre S.,
Leone L.,
Devecchi E.,
Degiuli A.,
D'Agostino F.,
Cambiè G.,
D'Agostino M.,
Faggi L.,
Colturani G.,
Gorini A.,
Villa R. F.
Publication year - 2003
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520180231
Subject(s) - genotype , allele , medicine , allele frequency , apolipoprotein e , vitamin e , case control study , genotype frequency , population , biology , endocrinology , disease , gastroenterology , genetics , biochemistry , gene , environmental health , antioxidant
Neurodegenerative Diseases represent the most commmon cause of Dementia, about 5–10% of the population aged above 65 years and about 30% above 80 years. A study about Apo‐E alleles, Coenzyme Q and Vitamins E as biological indicators was performed in plasma samples of patients aged from 30 to 85 years, affected by Neurodegenerative Diseases. The results were compared with control subjects of approximately the same ages as the reference group. A frequency of 21.7% of ϵ4 allele in control group was estimated, against 15.8% observed in patients. The frequency of ϵ2 and ϵ3 alleles was 13.0% and 65.2% in the control group against 10.5% and 73.7% in patients. No significant differences were observed between the frequency of ϵ3/ϵ3 genotype and ϵ3/ϵ4 genotype in the control group compared to patients' group. The frequencies observed in ϵ2/ϵ3 genotype groups were 8.7% vs 15.8% and of e2/e4 genotype 17.4% vs 5.3%. The ϵ2/ϵ2 and ϵ4/ϵ4 genotypes were not identified in any groups. Plasma CoQ 10 concentrations were similar in patient and control groups and no differences were found even taking into account the distribution of male and female subjects in the two groups. Also, vitamin E did not provide evidence of any differences between groups and the analysis among sexes revealed that again vitamin E concentrations were similar in between subgroups.