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The effect of Cyclosporine A chronic administration on the antioxidant pattern of rat liver mitochondria: Structural and functional consequences
Author(s) -
Battino Maurizio,
Bompadre Stefano,
Leone Luciana,
Pugnaloni Armanda,
Rubini Corrado,
Ferreiro Maria Soledad,
Gallardo Isabel,
Bullon Pedro
Publication year - 2003
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520180230
Subject(s) - antioxidant , ascorbic acid , mitochondrion , glutathione , uric acid , mitochondrial permeability transition pore , chemistry , pharmacology , biochemistry , vitamin c , endocrinology , medicine , biology , apoptosis , programmed cell death , food science , enzyme
Abstract Cyclosporine A (CsA) plays a pivotal role in controlling Ca 2+ movement in the cell modulating also the mitochondrial permeability transition pore. We investigated if chronic administration of CsA may have some effects on the lipophilic and hydrophilic antioxidant pattern of rat liver mitochondria and on their morphological structure. It seems that CsA administration does not statistically affect the redox status of the antioxidants investigated and their amounts (vitamin E, CoQ 9 , CoQ 10 , glutathione,uric acid and ascorbic acid) despite the variety of effects that this treatment produces at physiological and morphological levels. However, some kind of derangement could occur in the liver biochemical machinery since CsA treatment induces a markedly increased variability in antioxidant contents.