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Coenzyme Q 10 ‐containing composition (Immugen®) protects against occupational and environmental stress in workers of the gas and oil industry
Author(s) -
Korkina Ludmila,
Deeva Irina,
Ibragimova Galina,
Shakula Alexander,
Luci Antonio,
Luca Chiara De
Publication year - 2003
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520180227
Subject(s) - coenzyme q10 , oxidative stress , medicine , physiology
The manual workers of the gas‐and‐oil extraction industry are exposed to hostile environmental and occupational conditions, resulting in elevated mortality and disability, due to chronic neurological and cardiovascular diseases. We evaluated the degree of oxidative stress, often associated with these pathological features, in the blood of manual and office employees of Russian Siberian extraction plants, and their psycho‐physiological conditions. Results showed increased levels of spontaneous (p < 0.05) and PMA‐activated (p < 0.01) luminol‐dependent chemiluminescence (LDCL) in the white blood cells (WBC), and decreased peroxynitrite levels (p < 0.05) in the group of manual workers, and less markedly in the clerks and technicians working on spot, vs. a control group of city clerks. Superoxide release by WBC, and plasma/WBC membrane ubiquinol levels did not display major differences in the three groups. A relevant percentage of manual/office workers of extraction platforms presented impaired cardiovascular and neurological functions. The short term administration of a nutraceutical formulation based on coenzyme 10 , vitamin E, selenium, methionine and phospholipids led to significant improvement of cardiovascular parameters and psycho‐emotional status, consistent with the normalization of LDCL and peroxynitrite production by WBC, with a good compliance to treatment confirmed by the increased blood levels of ubiquinol.