Premium
Serum coenzyme Q 10 concentrations in healthy men supplemented with 30 mg or 100 mg coenzyme Q 10 for two months in a randomised controlled study
Author(s) -
Zita Čestmír,
Overvad Kim,
Mortensen Svend Aage,
Sindberg Christian Dan,
Moesgaard Sven,
Hunter Douglas A.
Publication year - 2003
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520180221
Subject(s) - coenzyme q10 , placebo , q10 , placebo group , medicine , gastroenterology , endocrinology , chemistry , respiration , alternative medicine , pathology , anatomy
Serum coenzyme Q 10 (Q 10 ) concentrations were evaluated in healthy male volunteers supplemented with 30 mg or 100 mg Q 10 or placebo as a single daily dose for two months in a randomised, double‐blind, placebo‐controlled study. Median baseline serum Q 10 concentration in 99 men was 1.26 mg/l (10%, 90% fractiles: 0.82, 1.83). Baseline serum Q 10 concentration did not depend on age, while borderline significant positive associations were found for body weight and smoking 1–10 cigarettes/d. Supplementation with 30 mg or 100 mg Q 10 resulted in median increases in serum Q 10 concentration of 0.55 mg/l and 1.36 mg/l, respectively, compared with a median decrease of 0.23 mg/l with placebo. The changes in the Q 10 groups were significantly different from that in the placebo group, and the increase in the 100 mg Q 10 group was significantly greater than that in the 30∼mg Q 10 group. The change in serum Q 10 concentration in the Q 10 groups did not depend on baseline serum 10 concentration, age, or body weight.