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Relaxation of arterial smooth muscle: A new function of a water‐soluble degradation product of coenzyme Q (ubiquinone)
Author(s) -
Bindu R.,
Venkataraman B. V.,
Rao Aparna V. S.,
Ramasarma T.
Publication year - 2003
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520180216
Subject(s) - coenzyme q – cytochrome c reductase , chemistry , derivative (finance) , degradation (telecommunications) , phenylephrine , coenzyme a , relaxation (psychology) , quinone , cofactor , coenzyme q10 , stereochemistry , biophysics , biochemistry , endocrinology , medicine , biology , blood pressure , mitochondrion , enzyme , telecommunications , cytochrome c , computer science , economics , financial economics , reductase
Treatment of coenzyme Q with ozone yielded a degradation product having unmodified ring that retained its spectral characteristics and a truncated side‐chain that made it water‐soluble. This derivative, but not the intact lipid‐quinone, showed relaxation of phenylephrine‐contracted rat arterial rings. This effect offers an explanation for the known hypotensive action of exogenous coenzyme Q regardless of its side‐chain length.