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Antidiabetogenic activity of oleanolic acid glycosides from medicinal foodstuffs
Author(s) -
Yoshikawa Masayuki,
Matsuda Hisashi
Publication year - 2000
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520130136
Subject(s) - oleanolic acid , glycoside , chemistry , gastric emptying , pharmacology , biochemistry , stereochemistry , biology , stomach , medicine , alternative medicine , pathology
Oleanolic acid glycosides from several medicinal foodstuffs were found to show potent inhibitory activity on the increase of serum glucose levels in oral glucose‐loaded rats. By examination of the structure‐activity relationships, the 3‐O‐glucuronide moiety and the 28‐carboxyl group in oleanolic acid glycosides were required to exert the hypoglycemic activity. Oleanolic acid glycosides were found to have neither insulin‐like nor insulin‐releasing activity, but they inhibited gastric emptying and glucose‐uptake in the small intestine. Investigation of the mode of action revealed that the inhibition of gastric emptying was mediated by capsaicin‐sensitive sensory nerves and the central nervous system. Furthermore, oleanolic acid glycosides were suggested to suppress the gastric emptying by stimulating the release and/or production of dopamine to act through dopamine2 receptors, which in turn causes the release of prostaglandins.