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Protein hydrolysates for oral tolerance
Author(s) -
Lipkowski A. W.,
Baranowska B.,
Marczak E.,
KwiatkowskaPatzer B.,
Gajkowska B.,
Walski M.
Publication year - 2000
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520120123
Subject(s) - hydrolysate , multiple sclerosis , experimental autoimmune encephalomyelitis , pepsin , immunization , oral tolerance , immune tolerance , spinal cord , antigen , oral administration , encephalomyelitis , chemistry , pharmacology , hydrolysis , medicine , immunology , biochemistry , enzyme , psychiatry
To induce oral tolerance in multiple sclerosis treatment, we proposed to use the predigested protein of pig spinal cord. The most biologically active composition was obtained from the hydrolysis of an undenaturated homogenate of proteins digested with pepsin. Feeding the rats with our preparation, before or after immunization with MS antigens, strongly reduced development of the experimental autoimmune encephalomyelitis (EAE). The biological results obtained in animals suggest that the developed method of induction of the oral tolerance should be effective in human treatment, at least as a support mechanism in combination with other treatment methods.