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Bioactive peptides derived from food proteins preventing lifestyle‐related diseases
Author(s) -
Yoshikawa Masaaki,
Fujita Hiroyuki,
Matoba Nobuyuki,
Takenaka Yasuyuki,
Yamamoto Taichi,
Yamauchi Rena,
Tsuruki Hirotaka,
Takahata Kyoya
Publication year - 2000
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520120122
Subject(s) - thermolysin , chemistry , enzyme , peptide , ovalbumin , oral administration , cholesterol , pharmacology , biochemistry , digestion (alchemy) , angiotensin converting enzyme , endocrinology , medicine , trypsin , blood pressure , chromatography , immunology , immune system
Many kinds of bioactive peptides which might prevent lifestyle‐related diseases are released from food proteins after enzymatic digestion. Inhibitory peptides for angiotensin I‐converting enzyme (ACE) having anti‐hypertensive effect have been isolated from enzymatic digests of various food proteins. LKPNM, which was isolated from the thermolysin digest of dried bonito was activated 8‐fold by ACE itself and showed a prolonged effect after oral administration. Two vasorelaxing peptides, ovokinin and ovokinin(2–7), showing antihypertensive effect after oral administration were obtained from ovalbumin digests. We found that low molecular weight peptides derived from food proteins lowered serum cholesterol without increasing excretion of cholesterol and bile acids. An immunostimulating peptide isolated from an enzymatic digest of soybean protein prevented alopecia induced by cancer chemotherapy.