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Clinical implications of the correlation between coenzyme Q 10 and vitamin B 6 status
Author(s) -
Willis R.,
Anthony M.,
Sun L.,
Honse Y.,
Qiao G.
Publication year - 1999
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520090236
Subject(s) - vitamin , coenzyme q – cytochrome c reductase , medicine , endocrinology , chemistry , biology , biochemistry , mitochondrion , cytochrome c
The endogenous biosynthesis of the quinone nucleus of coenzyme Q 10 (CoQ 10 ) from tyrosine is dependent on adequate vitamin B 6 nutriture. Lowered blood and tissue levels of CoQ 10 have been observed in a number of clinical conditions. Many of these clinical conditions are most prevalent among the elderly. Kalen et al. have shown that blood levels of CoQ 10 decline with age. Similarly, Kant et al. have shown that indicators of vitamin B 6 status also decline with age. Blood samples were collected from 29 patients who were not currently being supplemented with either CoQ 10 or vitamin B 6 . Mean CoQ 10 concentrations was 1.1 ± 0.3 μg/ml of blood. Mean specific activities of EGOT was 0.30 ± 0.13 μmol pyruvate/hr/10 8 erythrocytes and the mean percent saturation of EGOT with PLP was 78.2 ± 13.9%. Means for all parameters were within normal ranges. Strong positive correlation was found between CoQ 10 and the specific activity of EGOT ( r =0.5787, p <0.001) and between CoQ 10 and the percent saturation of EGOT with PLP ( r =0.4174, p <0.024). Studies are currently in progress to determine the effect of supplementation with vitamin B 6 of blood CoQ 10 levels. It appears prudent to recommend that patients receiving supplemental CoQ 10 be concurrently supplemented with vitamin B 6 to provide for better endogenous synthesis of CoQ 10 along with the exogenous CoQ 10 .