Premium
Protective effect of exogenous coenzyme Q in rats subjected to partial hepatic ischemia and reperfusion
Author(s) -
Genova Maria Luisa,
Bonacorsi Elisa,
D'Aurelio Marilena,
Formiggini Gabriella,
Nardo Bruno,
Cuccomarino Salvatore,
Turi Paola,
Pich Milena Merlo,
Lenaz Giorgio,
Bovina Carla
Publication year - 1999
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520090234
Subject(s) - ischemia , chemistry , reperfusion injury , medicine , pharmacology , endocrinology , cardiology
In a surgical model of liver ischemia lipid peroxidation occurs, as shown by increase of lipid peroxidation end products, endogenous CoQ 9 is oxidized and mitochondrial respiration is lowered; however, pre‐treatment of the rats by i.p. injection of CoQ 10 for 14 days normalizes the above parameters, presumably by way of the observed high extent of reduction of the incorporated quinone; moreover, liver homogenates of the CoQ 10 ‐treated rats are more resistant than those of non‐treated rats to oxidative stress induced by an azido free radical initiator. This preliminary study suggests that CoQ 10 pre‐treatment can be of beneficial effect against oxidative damage during liver surgery transplantation.