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High serum coenzyme Q 10 , positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study
Author(s) -
Pedersen H. S.,
Mortensen S. A.,
Rohde M.,
Deguchi Y.,
Mulvad G.,
Bjerregaard P.,
Hansen J. C.
Publication year - 1999
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520090230
Subject(s) - selenium , cholesterol , medicine , chemistry , organic chemistry
Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n‐6/n‐3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substantial impact. From a health survey we chose the subpopulation from the most remote area, where the traditional Greenlandic diet with high intake of sea mammals and fish predominates. The mean (SD) of S‐CoQ 10 in males was 1.495 (0.529) nmol/ml and 1.421 (0.629) nmol/ml in females, significantly higher (p<0.001) compared to a Danish population. In a linear multiple regression model the S‐CoQ 10 level is significantly positively associated with age and S‐selenium in males, and S‐total cholesterol in females. The high level of CoQ 10 in Greenlanders probably reflects diet, since no bioaccumulation takes place, and it could probably be a substantial part of the antioxidative defense.