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The effect of coenzyme Q 10 administration on metabolic control in patients with type 2 diabetes mellitus
Author(s) -
Eriksson J. G.,
Forsén T. J.,
Mortensen S. A.,
Rohde M.
Publication year - 1999
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520090229
Subject(s) - coenzyme q10 , glycemic , metabolic control analysis , medicine , type 2 diabetes mellitus , pathogenesis , placebo , diabetes mellitus , endocrinology , randomized controlled trial , gastroenterology , pathology , alternative medicine
A possible relationship between the pathogenesis of type 2 diabetes and coenzyme Q 10 (CoQ 10 ) deficiency has been proposed. The aim of this study was to assess the effect of CoQ 10 on metabolic control in 23 type 2 diabetic patients in a randomized, placebo‐controlled trial. Treatment with CoQ 10 100 mg bid caused a more than 3‐fold rise in serum CoQ 10 concentration (p<0.001). No correlation was observed between serum CoQ 10 concentration and metabolic control. No significant changes in metabolic parameters were observed during CoQ 10 supplementation. The treatment was well tolerated and did not interfere with glycemic control, therefore CoQ 10 may be used as adjunctive therapy in patients with associated cardiovascular diseases.