Premium
Plasma ubiquinol‐10 as a marker for disease: Is the assay worthwhile?
Author(s) -
Kontush Anatol,
Schippling Sven,
Spranger Torsten,
Beisiegel Ulrike
Publication year - 1999
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520090217
Subject(s) - ubiquinol , medicine , chemistry , biochemistry , coenzyme q – cytochrome c reductase , mitochondrion , cytochrome c
Ubiquinol‐10 and ubiquinone‐10 were measured in plasma of patients with several pathologies known to be associated with increased oxidative stress. Plasma ubiquinol‐10, expressed as a percentage of total ubiquinol‐10 + ubiquinone‐10, was found to be significantly lower in hyperlipidaemic patients and in patients with liver diseases than in age‐matched control subjects. In contrast, no decrease in ubiquinol‐10 was detected in plasma of patients with coronary heart disease and Alzheimer's disease. Except for ubiquinol‐10, no other lipophilic antioxidant was found to be decreased in patients with liver diseases. These data suggest that the level of ubiquinol‐10 in human plasma may serve as a marker for liver dysfunction, reflecting its diminished reduction by the liver rather than increased consumption by oxidants.