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Mitochondrial coenzyme Q content and aging
Author(s) -
Lass Achim,
Kwong Linda,
Sohal Rajindar S.
Publication year - 1999
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520090215
Subject(s) - coenzyme q – cytochrome c reductase , mitochondrion , chemistry , biochemistry , microbiology and biotechnology , biology , cytochrome c
The main objective of this study was to determine the nature of the relationship between aging and mitochondrial coenzyme Q (CoQ) content. Mitochondria in the heart, skeletal muscle, kidney and brain of the mouse varied in both the amount of total CoQ (CoQ 9 +CoQ 10 ) content as well as in the ratio of the CoQ 9 to CoQ 10 . CoQ content declined with age only in the skeletal muscle. Caloric restriction (CR) resulted in an increase in the amount of CoQ 9 in skeletal muscle mitochondria. This effect was partially reversible upon termination of the caloric restriction regimen. Results suggest that a decrease in mitochondrial CoQ content is an integral aspect of aging in skeletal muscle.