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The mitochondrial permeability transition
Author(s) -
Bernardi Paolo,
Colonna Raffaele,
Costantini Paola,
Eriksson Ove,
Fontaine Eric,
Ichas François,
Massari Stefano,
Nicolli Annamaria,
Petronilli Valeria,
Scorrano Luca
Publication year - 1998
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.5520080315
Subject(s) - mitochondrial permeability transition pore , bioenergetics , microbiology and biotechnology , intracellular , mitochondrion , oxidative stress , programmed cell death , chemistry , permeability (electromagnetism) , cell injury , calcium in biology , biophysics , biology , apoptosis , biochemistry , membrane
This review summarizes recent work on the regulation of the permeability transition pore, a cyclosporin A‐sensitive mitochondrial channel that may play a role in intracellular calcium homeostasis and in a variety of forms of cell death. The basic bioenergetics aspects of pore modulation are discussed, with some emphasis on the links between oxidative stress and pore dysregulation as a potential cause of mitochondrial dysfunction that may be relevant to cell injury.
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