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The function of vascular endothelial growth factor
Author(s) -
Nieves Bonnie J.,
D'Amore Patricia A.,
Bryan Brad A.
Publication year - 2009
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.46
Subject(s) - regulator , angiogenesis , vascular endothelial growth factor , master regulator , vegf receptors , growth factor , function (biology) , macular degeneration , cancer research , vascular endothelial growth factor a , medicine , biology , microbiology and biotechnology , transcription factor , biochemistry , ophthalmology , gene , receptor
Vascular endothelial growth factor (VEGF) is considered the master regulator of angiogenesis during growth and development, as well as in disease states such as cancer, diabetes, and macular degeneration. This review details our current understanding of VEGF signaling and discusses the benefits and unexpected side effects of promising anti‐angiogenic therapeutics that are currently being used to inhibit neovacularization in tumors. © 2009 International Union of Biochemistry and Molecular Biology, Inc.