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C/EBPα in leukemogenesis: Identity and origin of the leukemia‐initiating cell
Author(s) -
Schuster Mikkel Bruhn,
Porse Bo Torben
Publication year - 2009
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.36
Subject(s) - cebpa , myeloid leukemia , runx1 , myelopoiesis , biology , epigenetics , transcription factor , leukemia , cancer research , myeloid , ccaat enhancer binding proteins , genetics , population , gene , medicine , dna binding protein , haematopoiesis , stem cell , environmental health
The role of the transcription factor C CATT/enhancer binding protein alpha (C/EBPα) as a lineage instructive determinant in myelopoiesis is widely accepted. Furthermore, early mutational events ultimately leading to acute myeloid leukemia (AML) often involve abrogation of C/EBPα expression and/or function. The main focus of this review is the progression from a preclinical state to AML, and which preleukemic cell population(s) might—in general and in particular in patients with CEBPA mutations—be a target for the secondary genetic and epigenetic events leading to this progression. © 2009 International Union of Biochemistry and Molecular Biology, Inc.