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Mitochondrial dysfunction and Down's syndrome: Is there a role for coenzyme Q 10 ?
Author(s) -
Tiano Luca,
Busciglio Jorge
Publication year - 2011
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.184
Subject(s) - coenzyme q10 , coenzyme q – cytochrome c reductase , oxidative stress , mitochondrion , oxidative phosphorylation , antioxidant , mitochondrial dna , mitochondrial respiratory chain , biology , biochemistry , chemistry , gene , cytochrome c
Structural changes and abnormal function of mitochondria have been documented in Down's syndrome (DS) cells, patients, and animal models. DS cells in culture exhibit a wide array of functional mitochondrial abnormalities including reduced mitochondrial membrane potential, reduced ATP production, and decreased oxido‐reductase activity. New research has also brought to central stage the prominent role of oxidative stress in this condition. This review focuses on recent advances in the field with a particular emphasis on novel translational approaches involving the utilization of coenzyme Q 10 (CoQ 10 ) to treat a variety of clinical phenotypes associated with DS that are linked to increased oxidative stress and energy deficits. CoQ 10 has already provided promising results in several different conditions associated with altered energy metabolism and oxidative stress in the CNS. Two studies conducted in Ancona investigated the effect of CoQ 10 treatment on DNA damage in DS patients. Although the effect of CoQ 10 was evidenced only at single cell level, the treatment affected the distribution of cells according to their content in oxidized bases. In fact, it produced a strong negative correlation linking cellular CoQ 10 content and the amount of oxidized purines. Results suggest that the effect of CoQ 10 treatment in DS not only reflects antioxidant efficacy, but likely modulates DNA repair mechanisms.