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Therapeutic effects of Crocin in autoimmune diseases: A review
Author(s) -
Korani Shahla,
Korani Mitra,
Sathyapalan Thozhukat,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1557
Subject(s) - crocin , rheumatoid arthritis , medicine , ulcerative colitis , immunology , multiple sclerosis , arthritis , therapeutic effect , immune system , asthma , traditional medicine , pharmacology , disease
The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple sclerosis. Improved recognition of the mechanisms of ADs has led to the advancement of the management of these diseases. The principal mediators of ADs are inflammatory molecules. The herbal medicines due to their antioxidant and antiinflammatory properties have an important role in the management of ADs. Crocin is the principal chemical component extracted from saffron, which is a medicinal plant. This review focuses on the therapeutic effects of Crocin in various ADs.