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Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology
Author(s) -
Otasevic Vesna,
Stancic Ana,
Korac Aleksandra,
Jankovic Aleksandra,
Korac Bato
Publication year - 2019
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1535
Subject(s) - infertility , reactive oxygen species , sperm , male infertility , fertility , biology , oxidative stress , reproductive medicine , andrology , bioinformatics , physiology , microbiology and biotechnology , medicine , endocrinology , genetics , pregnancy , population , environmental health
Infertility is a significant global health problem that currently affects one of six couples in reproductive age. The quality of male reproductive cells dramatically decreased over the last years and almost every aspect of modern life additionally worsen sperm functional parameters that consequently markedly increase male infertility. This clearly points out the importance of finding a new approach to treat male infertility. Redox signaling mediated by reactive oxygen, nitrogen and sulfur species (ROS, RNS, and RSS respectively), has appeared important for sperm reproductive function. Present review summarizes the current knowledge of ROS, RNS, and RSS in male reproductive biology and identifies potential targets for development of novel pharmacological and therapeutic approaches for male infertility by targeted therapeutic modulation of redox signaling.