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Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach
Author(s) -
Forouzanfar Fatemeh,
Barreto George,
Majeed Muhammed,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1522
Subject(s) - curcumin , heat shock protein , hsp60 , hsp27 , angiogenesis , cancer cell , cancer research , cancer , hsp70 , motility , metastasis , hsp90 , biology , chemistry , microbiology and biotechnology , pharmacology , biochemistry , gene , genetics
Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress‐inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti‐inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.