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Calcium signaling dysfunction in heart disease
Author(s) -
Cartwright Elizabeth J.,
Mohamed Tamer,
Oceandy Delvac,
Neyses Ludwig
Publication year - 2011
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.149
Subject(s) - calcium , disease , calcium signaling , medicine , cardiology , neuroscience , biology
In the heart, Ca 2+ is crucial for the regulation of contraction and intracellular signaling, processes, which are vital to the functioning of the healthy heart. Ca 2+ ‐activated signaling pathways must function against a background of large, rapid, and tightly regulated changes in intracellular free Ca 2+ concentrations during each contraction and relaxation cycle. This review highlights a number of proteins that regulate signaling Ca 2+ in both normal and pathological conditions including cardiac hypertrophy and heart failure, and discusses how these pathways are not regulated by the marked elevation in free intracellular calcium ([Ca 2+ ] i ) during contraction but require smaller sustained increases in Ca 2+ concentration. In addition, we present published evidence that the pool of Ca 2+ that regulates signaling is compartmentalized into distinct cellular microdomains and is thus distinct from that regulating contraction.