Premium
Calcium signaling in cognition and aging‐dependent cognitive decline
Author(s) -
Oliveira Ana MM,
Bading Hilmar
Publication year - 2011
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.148
Subject(s) - nfat , creb , transcription factor , calcium signaling , neuroscience , calcium , signal transduction , biology , cognitive decline , microbiology and biotechnology , psychology , medicine , genetics , dementia , disease , gene
Calcium‐dependent signals are key triggers of the molecular mechanisms underlying learning and memory and dysregulation of calcium homeostasis in the aging brain has been proposed to underlie aging‐dependent cognitive decline. Mechanisms triggered by calcium in neurons include activity‐dependent activation of transcription responsible for the synthesis of molecules underlying the long‐term changes of neuronal function. Effectors of calcium signaling with a primordial role in transcription regulation are calcium signal‐regulated transcription factors. In this review, we summarize the current knowledge of the contribution of key calcium signal‐regulated transcription factors, namely CREB, NFAT, and DREAM, to memory formation. We further describe evidence for dysregulation of the activity of these factors during aging.