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Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways
Author(s) -
Oyagbemi Ademola Adetokunbo,
Omobowale Temidayo Olutayo,
OlaDavies Olufunke Eunice,
Asenuga Ebunoluwa Racheal,
Ajibade Temitayo Olabisi,
Adejumobi Olumuyiwa Abiola,
Arojojoye Oluwatosin Adetola,
Afolabi Jeremiah Moyinoluwa,
Ogunpolu Blessing Seun,
Falayi Olufunke Olubunmi,
Hassan Fasilat Oluwakemi,
Ochigbo Grace Onyeche,
Saba Adebowale Benard,
Adedapo Adeolu Alex,
Yakubu Momoh Audu
Publication year - 2018
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1445
Subject(s) - sodium fluoride , oxidative stress , quercetin , blood pressure , endocrinology , medicine , antioxidant , kidney , pharmacology , chemistry , fluoride , biochemistry , inorganic chemistry
Hypertension is one of the silent killers in the world with high mortality and morbidity. The exposure of humans and animals to fluoride and/or fluoride containing compounds is almost inevitable. This study investigated the modulatory effects of quercetin on sodium fluoride (NaF)‐induced hypertension and cardiovascular complications. Forty male rats were randomly separated into four groups ( n =10). Group A animals served as the control, rats in Group B were exposed to 300 ppm of NaF, Groups C and D animals were exposed to 300 ppm of NaF along with quercetin orally at 50 mg/kg and 100 mg/kg orally by gavage, while NaF was administered in drinking water, respectively, for a week. Administration of NaF caused severe hypertension as indicated with significant increases in the systolic, diastolic, and mean arterial blood pressure, together with prolonged ventricular depolarization (QRS) and the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle (QT) intervals when compared with controls. NaF significantly decreased the activities of antioxidant enzymes, caused increase in markers of oxidative stress and renal damage when compared with controls. Immunohistochemical staining revealed lower expressions of Hsp70, ERK, and PPARγ in the heart, kidney, and aorta of rats‐administered NaF relative to the controls. Together, quercetin co‐treatment with NaF restored blood pressure, normalized QRS interval, and improved antioxidant defense system. © 2018 BioFactors, 44(5):465–479, 2018