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Effect of resveratrol and pterostilbene on aging and longevity
Author(s) -
Li YiRong,
Li Shiming,
Lin ChiChien
Publication year - 2017
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1400
Subject(s) - pterostilbene , resveratrol , oxidative stress , medicine , disease , diabetes mellitus , inflammation , fisetin , type 2 diabetes , pharmacology , antioxidant , biology , endocrinology , biochemistry , quercetin
Over the past years, several studies have found that foods rich in polyphenols protect against age‐related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti‐aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and high‐calorie diets. Moreover, we also discuss the positive effect of resveratrol and pterostilbene on lifespan, aged‐related disease, and health maintenance. Furthermore, we summarize a variety of important mechanisms modulated by resveratrol and pterostilbene possibly involved in attenuating age‐associated disorders. Overall, we describe resveratrol and pterostilbene potential for prevention or treatment of several age‐related diseases by modulating age‐related mechanisms. © 2017 BioFactors, 44(1):69–82, 2018