Premium
New insights on the roles of BMP signaling in bone—A review of recent mouse genetic studies
Author(s) -
Kamiya Nobuhiro,
Mishina Yuji
Publication year - 2011
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.139
Subject(s) - bone morphogenetic protein , rankl , osteoblast , bone morphogenetic protein 7 , bone morphogenetic protein 2 , bone resorption , microbiology and biotechnology , bmpr2 , osteoclast , signal transduction , bone remodeling , biology , endocrinology , medicine , genetics , receptor , gene , activator (genetics) , in vitro
Abstract It is well known that Bone morphogenetic proteins (BMPs) induce bone formation and that some BMPs, including BMP2 and BMP7, are clinically used in orthopedics. Signaling by BMPs plays an important role in a variety of cell‐types in bone such as osteoblasts, chondrocytes, and osteoclasts. It is recently reported using an osteoblast‐targeted deletion of BMP signaling that BMP signaling in osteoblasts physiologically induces bone resorption by enhancing osteoclastogenesis via the RANKL‐OPG pathway and reduces bone mass. In this review, The physiological function of BMP signaling in bone will be focused, and the current outcomes from mouse genetic studies will be discuss.