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The potential role of mangiferin in cancer treatment through its immunomodulatory, anti‐angiogenic, apoptopic, and gene regulatory effects
Author(s) -
Núñez Selles Alberto J.,
Daglia Maria,
Rastrelli Luca
Publication year - 2016
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1299
Subject(s) - mangiferin , medicine , pharmacology , cancer , in vivo , traditional medicine , prostate cancer , cancer research , biology , microbiology and biotechnology
Mangiferin (1,3,6,7‐tetrahydroxyxanthone‐C2‐β‐D‐glucoside) is a natural bioactive xanthonoid that can be found in many plant species, among which the mango tree ( Mangifera indica L), a plant widely used in the traditional medicinal, is one of its primary sources. The use of mangiferin for cancer treatment has attracted the attention of research groups around the World. Single administration of mangiferin or in combination with known anticancer chemicals has shown the potential benefits of this molecule in lung, brain, breast, cervix, and prostate cancers, and leukemia. Mangiferin mechanisms of action against cancer cells through in vitro , ex vivo , or in vivo models are discussed besides its antioxidant and anti‐inflammatory properties. Nevertheless, pharmaceutical development and, therefore, clinical trials on cancer targets are still lacking. © 2016 BioFactors, 42(5):475–491, 2016