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Bioregulators of stem and progenitor cells in preservation solution reduce cold ischemia‐reperfusion injury of isolated rat livers
Author(s) -
Cherkashina Daria V.,
Sosimchyk Irina A.,
Semenchenko Olga A.,
Semenchenko Alexander Yu.,
Volina Victoria V.,
Petrenko Alexander Yu.
Publication year - 2016
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1272
Subject(s) - paracrine signalling , progenitor cell , stem cell , oxidative phosphorylation , microbiology and biotechnology , progenitor , reperfusion injury , cold storage , ischemia , viaspan , biology , cytosol , pharmacology , andrology , medicine , biochemistry , receptor , horticulture , enzyme
The effects of bioregulators of stem and progenitor cells (BSPC) of fetal tissue cytosol on rat liver during 24h hypothermic storage (HS) and following normothermic reperfusion (NR) were investigated. It was shown that BSPC presence in the preservation medium stabilized pro‐oxidant‐antioxidant balance impaired in liver after HS and NR, prevented the uncoupling of mitochondrial oxidative phosphorylation and ATP level decline. These consequences led to significant improvement of hepatic morphological integrity and functional state. Powerful protective effect of BSPC on liver at sub‐zero temperatures can serve as basis for new approaches to extend safe time for organ preservation and foster understanding of pathways of stem and progenitor cell paracrine action. © 2016 BioFactors, 42(3):287–295, 2016