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Coenzyme Q 10 redox state predicts the concentration of c‐reactive protein in a large caucasian cohort
Author(s) -
Fischer Alexandra,
Onur Simone,
Niklowitz Petra,
Menke Thomas,
Laudes Matthias,
Döring Frank
Publication year - 2016
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1269
Subject(s) - ubiquinol , c reactive protein , medicine , population , redox , chemistry , endocrinology , inflammation , biochemistry , coenzyme q – cytochrome c reductase , cytochrome c , environmental health , organic chemistry , mitochondrion
In the present study the relationship between the CoQ 10 redox state (% oxidized form of CoQ 10 ) and the serum level of c‐reactive protein (CRP) was investigated in a large Caucasian study population ( n = 1319). In order to evaluate independently the influence of the variables that predict the outcome of CRP, an analysis of covariance (ANCOVA) was performed with CRP as the dependent variable. Gender was taken as an independent factor and CoQ 10 redox and BMI as independent covariates. Results were substantiated with findings from a human intervention study ( n = 53), receiving 150 mg/day ubiquinol for 14 days. Spearman's correlation revealed a significant ( P < 0.001) association between the CoQ 10 redox state and CRP concentrations in the whole study population. Thus, higher CRP concentrations were found in subjects having more oxidized CoQ 10 . Similar results were evident for further inflammatory markers (interleukin‐6, number of leucocytes). The ANCOVA revealed a significant ( P < 0.001) prediction of CRP concentrations by CoQ 10 redox state, after controlling for the effect of BMI and separately for gender. In the intervention study it was further found that the oral intake of ubiquinol increased its proportion significantly ( P < 0.001), with the highest increase in those persons having a low basal serum ubiquinol content (<92.3%). Here it was discovered that the ubiquinol status significantly correlated to the concentration of the inflammation marker monocyte chemotactic protein 1. It is concluded that CoQ 10 redox state predicts the concentration of CRP. Persons at risk with lower ubiquinol status, higher BMI, and low grade inflammation may benefit from ubiquinol supplementation. © 2016 BioFactors, 42(3):268–276, 2016