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Proanthocyanidins in health and disease
Author(s) -
Bladé Cinta,
Aragonès Gerard,
ArolaArnal Anna,
Muguerza Begoña,
Bravo Francisca Isabel,
Salvadó M. Josepa,
Arola Lluis,
Suárez Manuel
Publication year - 2016
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1249
Subject(s) - proanthocyanidin , polyphenol , human health , health benefits , microrna , epigenetics , biology , biochemistry , pharmacology , chemistry , medicine , traditional medicine , gene , antioxidant , environmental health
Proanthocyanidins (PAs) are the most abundant flavonoids in the human diet. Several epidemiological studies connect PA consumption and health benefits and the designation of PAs as healthy compounds started at the early stages of the 20th century. The beneficial health properties of PAs are attributed to their conjugated and colonic metabolites. Therefore, gut microbial compositions can determine the effectiveness of PAs. Reciprocally, dietary polyphenols can act as prebiotics. Recently, it has also been described that PAs modulate the circadian rhythm. Biochemical and epigenetic mechanisms, including the modulation of microRNAs, allow PAs to modulate cell functionality. PA effects in metabolic diseases are also reviewed. © 2016 BioFactors, 42(1):5–12, 2016