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Topical treatment with coenzyme Q 10‐containing formulas improves skin's Q 10 level and provides antioxidative effects
Author(s) -
Knott Anja,
Achterberg Volker,
Smuda Christoph,
Mielke Heiko,
Sperling Gabi,
Dunckelmann Katja,
Vogelsang Alexandra,
Krüger Andrea,
Schwengler Helge,
Behtash Mojgan,
Kristof Sonja,
Diekmann Heike,
Eisenberg Tanya,
Berroth Andreas,
Hildebrand Janosch,
Siegner Ralf,
Winnefeld Marc,
Teuber Frank,
Fey Sven,
Möbius Janne,
Retzer Dana,
Burkhardt Thorsten,
Lüttke Juliane,
Blatt Thomas
Publication year - 2015
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1239
Subject(s) - coenzyme q10 , ubiquinol , antioxidant , chemistry , human skin , epidermis (zoology) , oxidative stress , q10 , metabolism , biochemistry , pharmacology , coenzyme q – cytochrome c reductase , apoptosis , biology , botany , anatomy , cytochrome c , respiration , genetics
Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid‐soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10‐containing formulas significantly increased the levels of this quinone on the skin surface. In the deeper layers of the epidermis the ubiquinone level was significantly augmented indicating effective supplementation. Concurrent elevation of ubiquinol levels suggested metabolic transformation of ubiquinone resulting from increased energy metabolism. Incubation of cultured human keratinocytes with Q10 concentrations equivalent to treated skin showed a significant augmentation of energy metabolism. Moreover, the results demonstrated that stressed skin benefits from the topical Q10 treatment by reduction of free radicals and an increase in antioxidant capacity. © 2015 BioFactors, 41(6):383–390, 2015