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ABCA1 and nascent HDL biogenesis
Author(s) -
Wang Shuhui,
Smith Jonathan D.
Publication year - 2014
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1187
Subject(s) - abca1 , lipid anchored protein , cholesterol , biogenesis , reverse cholesterol transport , microbiology and biotechnology , efflux , tangier disease , chemistry , high density lipoprotein , apolipoprotein b , biochemistry , secretion , abcg1 , lipoprotein , biology , transporter , autophagy , gene , apoptosis
ABCA1 mediates the secretion of cellular free cholesterol and phospholipids to an extracellular acceptor, apolipoprotein AI, to form nascent high‐density lipoprotein (HDL). Thus, ABCA1 is a key molecule in cholesterol homeostasis. Functional studies of certain Tangier disease mutations demonstrate that ABCA1 has multiple activities, including plasma membrane remodeling and apoAI binding to cell surface, which participate in nascent HDL biogenesis. Recent advances in our understanding of ABCA1 have demonstrated that ABCA1also mediates unfolding the N terminus of apoAI on the cell surface, followed by lipidation of apoAI and release of nascent HDL. Although ABCA1‐mediated cholesterol efflux to apoAI can occur on the plasma membrane, the role of apoAI retroendocytosis during cholesterol efflux may play a role in macrophage foam cells that store cholesterol esters in cytoplasmic lipid droplets. © 2014 BioFactors, 40(6):547–554, 2014