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Regulation of mitochondrial morphology by lipids
Author(s) -
Ha Elizabeth E.J.,
Frohman Michael A.
Publication year - 2014
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1169
Subject(s) - cardiolipin , phosphatidic acid , lysophosphatidic acid , phosphatidylethanolamine , microbiology and biotechnology , biology , biochemistry , diacylglycerol kinase , mitochondrial fission , mitochondrial fusion , enzyme , chemistry , mitochondrion , phospholipid , phosphatidylcholine , mitochondrial dna , gene , receptor , protein kinase c , membrane
Abstract Although great progress has been made in identifying key protein factors that regulate mitochondrial morphology through mediating fission and fusion, signaling lipids are increasingly being recognized as important in the process as well. We review here roles that have been proposed for the signaling and bulk lipids cardiolipin, phosphatidic acid, lysophosphatidic acid, diacylglycerol, and phosphatidylethanolamine and the enzymes that generate or catabolize them in the regulation of mitochondrial morphology in yeast and mammals. Mutations in some of these enzymes are causal in a number of disease settings, highlighting the significance of controlling the lipid environment in this setting. © 2014 BioFactors, 40(4):419–424, 2014