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Expanded complexity of unstable repeat diseases
Author(s) -
Polak Urszula,
McIvor Elizabeth,
Dent Sharon Y.R.,
Wells Robert D.,
Napierala Marek
Publication year - 2012
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1060
Subject(s) - microsatellite instability , computational biology , genome instability , biology , transcriptome , mechanism (biology) , genome , proteome , disease , microsatellite , genetics , bioinformatics , medicine , dna , gene , pathology , gene expression , dna damage , allele , philosophy , epistemology
Unstable repeat diseases (URDs) share a common mutational phenomenon of changes in the copy number of short, tandemly repeated DNA sequences. More than 20 human neurological diseases are caused by instability, predominantly, expansion of microsatellite sequences. Changes in the repeat size initiate a cascade of pathological processes, frequently characteristic of a unique disease or a small subgroup of the URDs. Understanding of both the mechanism of repeat instability and molecular consequences of the repeat expansions is critical to developing successful therapies for these diseases. Recent technological breakthroughs in whole genome, transcriptome and proteome analyses will almost certainly lead to new discoveries regarding the mechanisms of repeat instability, the pathogenesis of URDs, and will facilitate development of novel therapeutic approaches. The aim of this review is to give a general overview of unstable repeats diseases, highlight the complexities of these diseases, and feature the emerging discoveries in the field. © 2012 BioFactors, 2013