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Olive oil supplemented with Coenzyme Q 10 : Effect on plasma and lipoprotein oxidative status
Author(s) -
Brugè Francesca,
Bacchetti Tiziana,
Principi Federica,
Scarpa EmanueleSalvatore,
Littarru Gian Paolo,
Tiano Luca
Publication year - 2012
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1015
Subject(s) - chemistry , lipid peroxidation , antioxidant , bioavailability , lipoprotein , food science , medicine , endocrinology , cholesterol , biochemistry , pharmacology
Olive oil consumption is associated with protective cardiovascular properties, including some beneficial modifications in lipoprotein profile and composition. Coenzyme Q 10 (CoQ 10 ) exerts a protective effect on plasma lipoproteins. Aim of the study was to investigate whether extra virgin (EV) olive oil enriched with CoQ 10 affects CoQ 10 levels and oxidative status in plasma and in isolated lipoproteins. Twelve subjects were administered 20 mL olive oil per day for 2 weeks, followed by 2 weeks of olive oil enriched with 20 mg and 2 more weeks with 40 mg of CoQ 10 . Plasma and isolated lipoproteins were collected in each phase of the study and subsequently analyzed to assess lipid profile, CoQ10 levels, ORAC assay, resistance of lipoproteins to peroxidation and paroxonase 1 activity. Plasma CoQ 10 levels significantly increased with the 20 mg (+73%) and 40 mg dose (+170%), while the percentage of oxidized CoQ 10 decreased. A significant inverse correlation was found in plasma between percentage of oxidized CoQ 10 and total antioxidant capacity. A lower susceptibility of LDL to peroxidation was also found. Finally, a positive correlation was observed between concentration of CoQ 10 in HDL and paraoxonase‐1 activity. EV olive oil enriched with both doses of CoQ 10 significantly affects its bioavailability and plasma redox status. These changes are associated with a decreased susceptibility of plasma lipoproteins to peroxidation associated with a chain‐breaking antioxidant activity of the formulation. © 2012 International Union of Biochemistry and Molecular Biology, Inc.