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Role of mitochondrial ion channels in cell death
Author(s) -
Ryu ShinYoung,
Peixoto Pablo M.,
Teijido Oscar,
Dejean Laurent M.,
Kinnally Kathleen W.
Publication year - 2010
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.101
Subject(s) - mptp , mitochondrial permeability transition pore , microbiology and biotechnology , crosstalk , programmed cell death , voltage dependent anion channel , mitochondrion , cytosol , mitochondrial membrane transport protein , apoptosis , ion channel , inner mitochondrial membrane , biology , signal transduction , chemistry , bacterial outer membrane , neuroscience , biochemistry , receptor , physics , dopaminergic , escherichia coli , gene , dopamine , optics , enzyme
Ion channels located in the outer and inner mitochondrial membranes are key regulators of cellular signaling for life and death. Permeabilization of mitochondrial membranes is one of the most critical steps in the progression of several cell death pathways. The mitochondrial apoptosis‐induced channel (MAC) and the mitochondrial permeability transition pore (mPTP) play major roles in these processes. Here, the most recent progress and current perspectives about the roles of MAC and mPTP in mitochondrial membrane permeabilization during cell death are presented. The crosstalk signaling of MAC and mPTP formation/activation mediated by cytosolic Ca 2+ signaling, Bcl‐2 family proteins, and other mitochondrial ion channels is also discussed. Understanding the mechanisms that regulate opening and closing of MAC and mPTP has revealed new therapeutic targets that potentially could control cell death in pathologies such as cancer, ischemia/reperfusion injuries, and neurodegenerative diseases.