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Direct chemiluminescence determination of ibuprofen by the enhancement of the KMnO 4 –sulphite reaction
Author(s) -
Li Yinhuan,
Lu Jiuru
Publication year - 2007
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.966
Subject(s) - chemiluminescence , ibuprofen , detection limit , chemistry , relative standard deviation , chromatography , analyte , urine , flow injection analysis , analytical chemistry (journal) , pharmacology , medicine , biochemistry
A simple, rapid, flow‐injection chemiluminescence (CL) method is described for the determination of ibuprofen. A strong CL signal was detected when a mixture of the analyte and sulphite was injected into acidic KMnO 4 . The CL signal is proportional to the concentration of ibuprofen in the range 0.1–10.0 mg/L. The detection limit is 0.02 mg/L ibuprofen, the relative standard deviation is 1.8% (0.5 mg/L ibuprofen; n = 11) and the sample measurement frequency is 120/h. The proposed method was successfully applied to the determination of ibuprofen in pharmaceutical preparations and in spiked urine samples. The mechanism of the CL reaction is also discussed. Copyright © 2007 John Wiley & Sons, Ltd.