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Neopterin in renal cell carcinoma: inhalational administration of interleukin‐2 is not accompanied by a rise of urinary neopterin
Author(s) -
Melichar Bohuslav,
Solichová Dagmar,
Svobodová Iveta,
Melicharová Karolina
Publication year - 2005
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.852
Subject(s) - neopterin , creatinine , medicine , urinary system , renal cell carcinoma , gastroenterology , urology , toxicity , endocrinology
Inhalational administration of interleukin‐2 (IL‐2) is effective in controlling renal cell carcinoma (RCC) lung metastases with minimal toxicity. Neopterin is an indicator of systemic immune activation in metastatic cancer and is increased after systemic IL‐2 administration. Urinary neopterin was investigated in 13 patients with metastatic RCC and 18 controls. In seven patients, urinary neopterin was followed before and after treatment with inhalational IL‐2. Neopterin was measured by highperformance liquid chromatography and creatinine was determined by Jaffé reaction. Urinary neopterin was significantly increased in patients with metastatic RCC compared to controls (257 ± 263 µmol/mol creatinine vs. 110 ± 41 µmol/mol creatinine; Mann–Whitney U‐test, p < 0.05). Median survival was significantly longer in patients with urinary neopterin <173 µmol/mol creatinine compared to patients with neopterin ≥173 µmol/mol creatinine (698 vs. 245 days; log‐rank test, p < 0.05). No significant increase was observed after inhalational IL‐2 therapy (147 ± 101 vs. 153 ± 54 µmol/mol creatinine). We conclude that urinary neopterin is increased in patients with metastatic RCC, and higher neopterin concentrations are indicative of poor prognosis. The absence of an increase in urinary neopterin after inhalational IL‐2 therapy is in accord with the lack of significant systemic toxicity. Copyright © 2005 John Wiley & Sons, Ltd.