Use of molecule imprinting–chemiluminescence method for the determination of tamoxifen in breast cancer sufferers' urine | Zendy

Nie Fei | Zendy; Lu Jiuru | Zendy; He Yunhua | Zendy; Du Jianxiu | Zendy

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Use of molecule imprinting–chemiluminescence method for the determination of tamoxifen in breast cancer sufferers' urine

Author(s) -

Nie Fei,

Lu Jiuru,

He Yunhua,

Du Jianxiu

Publication year - 2005

Publication title -

luminescence

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.428

H-Index - 45

eISSN - 1522-7243

pISSN - 1522-7235

DOI - 10.1002/bio.837

Subject(s) - chemiluminescence , tamoxifen , detection limit , chemistry , chromatography , formaldehyde , molecular imprinting , coefficient of variation , relative standard deviation , breast cancer , selectivity , organic chemistry , cancer , medicine , catalysis

The reaction between soluble Mn(IV) and tamoxifen can produce chemiluminescence and formaldehyde can enhance this chemiluminescence reaction. A tamoxifen molecular imprinted polymer (MIP) was synthesized and its adsorption selectivity to tamoxifen in aqueous solution was evaluated. Using a synthesized tamoxifen MIP as the recognition material and a soluble Mn(IV)–formaldehyde–tamoxifen chemiluminesence system as the detection system, a new molecule imprinting–chemiluminesence method of determination of tamoxifen was established. The response range of this method was 1.0 × 10 −7 –6.0 × 10 −6 g/mL, with a linear correlation coefficient of 0.997. The detection limit was 4 × 10 −8 g/mL. The relative standard deviation for 5.0 × 10 −7 g/mL tamoxifen solution was 4.1% ( n = 9). Copyright © 2005 John Wiley & Sons, Ltd.

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