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Use of molecule imprinting–chemiluminescence method for the determination of tamoxifen in breast cancer sufferers' urine
Author(s) -
Nie Fei,
Lu Jiuru,
He Yunhua,
Du Jianxiu
Publication year - 2005
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.837
Subject(s) - chemiluminescence , tamoxifen , detection limit , chemistry , chromatography , formaldehyde , molecular imprinting , coefficient of variation , relative standard deviation , breast cancer , selectivity , organic chemistry , cancer , medicine , catalysis
The reaction between soluble Mn(IV) and tamoxifen can produce chemiluminescence and formaldehyde can enhance this chemiluminescence reaction. A tamoxifen molecular imprinted polymer (MIP) was synthesized and its adsorption selectivity to tamoxifen in aqueous solution was evaluated. Using a synthesized tamoxifen MIP as the recognition material and a soluble Mn(IV)–formaldehyde–tamoxifen chemiluminesence system as the detection system, a new molecule imprinting–chemiluminesence method of determination of tamoxifen was established. The response range of this method was 1.0 × 10 −7 –6.0 × 10 −6 g/mL, with a linear correlation coefficient of 0.997. The detection limit was 4 × 10 −8 g/mL. The relative standard deviation for 5.0 × 10 −7 g/mL tamoxifen solution was 4.1% ( n = 9). Copyright © 2005 John Wiley & Sons, Ltd.