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A study on the micelle‐sensitized Ce(IV)–Na 2 S 2 O 3 –norfloxacin chemiluminescence system and its applications
Author(s) -
Xie Zenghong,
Liao Sulan,
Chen Guonan
Publication year - 2005
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.824
Subject(s) - norfloxacin , chemiluminescence , chemistry , detection limit , chromatography , sodium , urine , nuclear chemistry , organic chemistry , biochemistry , antibiotics , ciprofloxacin
A new chemiluminescence (CL) flow‐injection method was developed for the determination of norfloxacin. The method is based on the CL reaction of norfloxacin with sodium thiosulphate and Ce(IV) in sulphuric acid medium sensitized by sodium dodecylsulphate. Under optimum conditions, the CL intensity is proportional to the concentration of the norfloxacin in the range 3.89 × 10 −8 –7.18 × 10 −6 g[sol ]mL. The detection limit (3 s[sol ]k) was 2.21 × 10 −9 g[sol ]mL for norfloxacin. The method has been applied successfully to the determination of norfloxacin in pharmaceutical formulations and human urine. The mechanism for this chemiluminescence system is discussed. Copyright © 2005 John Wiley & Sons, Ltd.