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Premium Simple ultrasensitive spectrofluorimetric method for determination of midodrine in its tablet form: Application to content uniformity testing
Omar Mahmoud A.,
Nagy Dalia M.,
Halim Monica E.
Publication year2019
Publication title
Resource typeJournals
Abstract A novel, simple, sensitive method was developed for determining midodrine spectrofluorimetrically in both its raw pure form and its tablet form. This study is based on the native fluorescence of midodrine and discusses the optimum solvent used and the wavelength range. The presented method was then validated with respect to linearity, accuracy, precision, and limits of detection and quantitation. The constructed calibration curve showed a linear range of 0.1–2.0 μg/ml. The limit of detection and limit of quantitation values were 0.03 and 0.10 μg/ml respectively. Finally, content uniformity testing was applied according to the United States Pharmacopoeia by adapting the presented method.
Subject(s)analytical chemistry (journal) , blood pressure , calibration , calibration curve , chemistry , chromatography , content determination , detection limit , high performance liquid chromatography , linearity , materials science , mathematics , medicine , midodrine , orthostatic vital signs , physics , quantum mechanics , radiology , statistics
SCImago Journal Rank0.428

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