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Ratiometric fluorescence detection of superoxide anion based on AuNPs‐BSA@Tb/GMP nanoscale coordination polymers
Author(s) -
Liu Nan,
Hao Juan,
Cai Keying,
Zeng Mulan,
Huang Zhenzhong,
Chen Lili,
Peng Bingxian,
Li Ping,
Wang Li,
Song Yonghai
Publication year - 2018
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.3380
Subject(s) - nanosensor , detection limit , fluorescence , chemistry , bovine serum albumin , terbium , colloidal gold , superoxide , nanoparticle , nuclear chemistry , ion , nanotechnology , materials science , chromatography , biochemistry , organic chemistry , physics , quantum mechanics , enzyme
A novel ratiometric fluorescence nanosensor for superoxide anion (O 2 •− ) detection was designed with gold nanoparticles‐bovine serum albumin (AuNPs‐BSA)@terbium/guanosine monophosphate disodium (Tb/GMP) nanoscale coordination polymers (NCPs) (AuNPs‐BSA@Tb/GMP NCPs). The abundant hydroxyl and amino groups of AuNPs‐BSA acted as binding points for the self‐assembly of Tb 3+ and GMP to form core‐shell AuNPs‐BSA@Tb/GMP NCP nanosensors. The obtained probe exhibited the characteristic fluorescence emission of both AuNPs‐BSA and Tb/GMP NCPs. The AuNPs‐BSA not only acted as a template to accelerate the growth of Tb/GMP NCPs, but also could be used as the reference fluorescence for the detection of O 2 •− . The resulting AuNPs‐BSA@Tb/GMP NCP ratiometric fluorescence nanosensor for the detection of O 2 •− demonstrated high sensitivity and selectivity with a wide linear response range (14 nM–10 μM) and a low detection limit (4.7 nM).