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A rhodamine‐triazole fluorescent chemodosimeter for Cu 2+ detection and its application in bioimaging
Author(s) -
Wechakorn Kanokorn,
Prabpai Samran,
Suksen Kanoknetr,
Kanjanasirirat Phongthon,
Pewkliang Yongyut,
Borwornpinyo Suparerk,
Kongsaeree Palangpon
Publication year - 2018
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.3373
Subject(s) - fluorescence , rhodamine , chemistry , detection limit , moiety , metal ions in aqueous solution , triazole , hydrazide , naked eye , click chemistry , selectivity , fluorophore , aqueous solution , photochemistry , conjugate , nuclear chemistry , metal , combinatorial chemistry , chromatography , stereochemistry , organic chemistry , catalysis , physics , quantum mechanics , mathematical analysis , mathematics
A rhodamine‐based fluorescent chemodosimeter rhodamine hydrazide‐triazole (RHT) tethered with a triazole moiety was developed for Cu 2+ detection. In aqueous medium, the RHT probe exhibited high selectivity and sensitivity toward Cu 2+ among other metal ions. The addition of Cu 2+ triggered a fluorescence emission of RHT by 384‐fold (Φ = 0.33) based on a ring‐opening process and a subsequent hydrolysis reaction. Moreover, RHT also showed a selective colorimetric response toward Cu 2+ from colorless solution to pink, readily observed with the naked eye. The limit of detection of RHT for Cu 2+ was calculated to be 1 nM (0.06 ppb). RHT was successfully demonstrated to detect Cu 2+ in Chang liver cells by confocal fluorescence microscopy.
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