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Enhanced chemiluminescence for trazodone trace analysis based on acidic permanganate oxidation in concurrent presence of rhodamine 6G
Author(s) -
Fujimori Keiichi,
Sakata Yuta,
MoriuchiKawakami Takayo,
Shibutani Yasuhiko
Publication year - 2017
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.3317
Subject(s) - chemiluminescence , rhodamine 6g , permanganate , potassium permanganate , chemistry , detection limit , calibration curve , rhodamine , rhodamine b , chromatography , fluorescence , analytical chemistry (journal) , photochemistry , inorganic chemistry , catalysis , organic chemistry , photocatalysis , molecule , physics , quantum mechanics
A new sensitized chemiluminescence method by acidic permanganate oxidation was developed for the sensitive determination of trazodone. A fluorescent dye as used rhodamine 6G to increase a chemiluminescence intensity. Under optimum conditions, the liner range of the calibration curve was obtained for 1–5000 nmol/L. The limit of detection was calculated from 3σ of a blank was 0.23 nmol/L. The coexistent ions and substances had no interference with the chemiluminescence measurement. The chemiluminescence spectra were measured to elucidate a possible mechanism for the system. The present method was satisfactorily used in the determination of the drugs in pharmaceutical samples and animal serums.