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Dual‐function fluorescent probe for cancer imaging and therapy
Author(s) -
Cui Hongjing,
Wang Ran,
Zhou Ying,
Shu Chang,
Song Fengjuan,
Zhong Wenying
Publication year - 2016
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.3028
Subject(s) - fluorescence , conjugate , cancer cell , biophysics , chemistry , bovine serum albumin , liver cancer , in vitro , cancer research , cancer , dual function , arginine , biochemistry , nanotechnology , amino acid , materials science , medicine , biology , computer science , mathematical analysis , physics , mathematics , quantum mechanics , hepatocellular carcinoma , computer graphics (images) , contouring
Abstract To date, several fluorescent probes modified by a single targeting agent have been explored. However, studies on the preparation of dual‐function quantum dot (QD) fluorescent probes with dual‐targeting action and a therapeutic effect are rare. Here, a dual‐targeting CdTe/CdS QD fluorescent probe with a bovine serum albumin–glycyrrhetinic acid conjugate and arginine‐glycine‐aspartic acid was successfully prepared that could induce the apoptosis of liver cancer cells and showed enhanced targeting in in vitro cell imaging. Therefore, the as‐prepared fluorescent probe in this work is an efficient diagnostic tool for the simultaneous detection of liver cancer and breast cancer cells. Copyright © 2015 John Wiley & Sons, Ltd.