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Nucleation temperature‐controlled synthesis and in vitro toxicity evaluation of l ‐cysteine‐capped Mn:ZnS quantum dots for intracellular imaging
Author(s) -
Pandey Vivek,
Pandey Gajanan,
Tripathi Vinay Kumar,
Yadav Sapna,
Mudiam Mohana Krishna Reddy
Publication year - 2016
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.2965
Subject(s) - quantum dot , fluorophore , nucleation , intracellular , cysteine , fluorescence , chemistry , nanotechnology , nanoparticle , biophysics , materials science , biochemistry , organic chemistry , physics , quantum mechanics , biology , enzyme
Quantum dots (QDs), one of the fastest developing and most exciting fluorescent materials, have attracted increasing interest in bioimaging and biomedical applications. The long‐term stability and emission in the visible region of QDs have proved their applicability as a significant fluorophore in cell labelling. In this study, an attempt has been made to explore the efficacy of l ‐cysteine as a capping agent for Mn‐doped ZnS QD for intracellular imaging. A room temperature nucleation strategy was adopted to prepare non‐toxic, water‐dispersible and biocompatible Mn:ZnS QDs. Aqueous and room temperature QDs with l ‐cysteine as a capping agent were found to be non‐toxic even at a concentration of 1500 µg/mL and have wide applications in intracellular imaging. Copyright © 2015 John Wiley & Sons, Ltd.