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Sensitive determination of carbidopa through the electrochemiluminescence of luminol at graphene‐modified electrodes
Author(s) -
Hosseini Morteza,
Mirzanasiri Nooshin,
Rezapour Morteza,
Sheikhha Mohammad Hasan,
Faridbod Farnoush,
Norouzi Parviz,
Ganjali Mohammad Reza
Publication year - 2015
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.2742
Subject(s) - electrochemiluminescence , luminol , detection limit , chemiluminescence , graphene , carbidopa , electrode , chemistry , oxide , analytical chemistry (journal) , materials science , chromatography , nanotechnology , organic chemistry , medicine , levodopa , disease , pathology , parkinson's disease
Using the concept of electrogenerated chemiluminescence (ECL), a sensitive analytical method for the determination of carbidopa is described. Electro‐oxidation of carbidopa on the surface of a graphene oxide (GO)‐modified gold electrode (GE) leads to enhancement of the weak emission of oxidized luminol. Under optimum experimental conditions, the ECL signal increases linearly with increasing carbidopa concentrations over a range of 1.0 × 10 ‐9 –1.7 × 10 ‐7 M, with a detection limit of 7.4 × 10 ‐10 M. The proposed ECL method was successfully used for the determination of carbidopa in urine samples. Copyright © 2014 John Wiley & Sons, Ltd.