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The interaction of CuInS 2 /ZnS/TGA quantum dots with tyrosine kinase inhibitor and its application
Author(s) -
Liao Shenghua,
Huang Yu,
Zuo Jiaxin,
Yan Zhengyu
Publication year - 2015
Publication title -
luminescence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 45
eISSN - 1522-7243
pISSN - 1522-7235
DOI - 10.1002/bio.2740
Subject(s) - quantum dot , tyrosine kinase inhibitor , chemistry , materials science , optoelectronics , medicine , cancer
The interactions between thioglycolic acid‐capped‐CuInS 2 /ZnS quantum dots (CuInS 2 /ZnS/TGA QDs) and tyrosine kinase inhibitor (TKI) were investigated using fluorescence, ultraviolet–visible spectrometry and Fourier transform infrared spectrometry. The results indicated that the fluorescence intensity of CuInS 2 /ZnS/TGA could be quenched by imatinib, dasatinib, nilotinib, gefitinib and erlotinib, which hinted that CuInS 2 /ZnS/TGA QDs could be used in the detection of TKI in active pharmaceutical ingredients (API). Calibration curves showed good linear correlation and low detection limits. The average recovery was between 98 and 102%. Moreover, the nature of the fluorescence quenching mechanism of CuInS 2 /ZnS/TGA QDs by TKI was discussed. A ground state complex was formed by hydrogen bonding between the carboxyl group of CuInS 2 /ZnS/TGA QDs and the amino group of TKI. This led to an increase in non‐radiative transition and fluorescence quenching of CuInS 2 /ZnS/TGA QDs. Copyright © 2014 John Wiley & Sons, Ltd.